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ea0090oc10.2 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 2 | ECE2023

Characterization of the insulinotropic and glucose lowering actions of hybridized amphibian host defence peptide, tigerinin-1R

Abiodun Falobi Ayodele , Edeani Joy Nneka , Ofosu Wendy Amy , Smyth Lesley , Corcoran Olivia , Dunmore Simon , Ojo Opeolu

Aim: Our previous studies indicated the potential antidiabetic actions of the amphibian host-defence peptide, tigerinin-1. Tigerinin-1R was conjugated with gastric inhibitory polypeptide (GIP) as part of strategies for further development of its therapeutic effects. This study characterises the insulin-releasing and cytotoxic properties of the resulting hybrid peptide.Method: Pure G-TGN was commercially synthesized G-TGN. Insulin releasing effects were a...

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ea0099p482 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

The conjugation of tigerinin-1r with modified gastric inhibitory polypeptide enhanced its cellular uptake and metabolic actions

Ojo Opeolu , Abiodun Falobi Ayodele , Nneka Edeani Joy , Amy Ofosu Wendy , Smyth Lesley , Corcoran Olivia , Dunmore Simon

Aim: Previous reports indicate therapeutic potentials of tigerinin-1R, isolated from the skin secretions of Hoplobatrachus rugulosus, as an antidiabetic agent. Despite the report of its insulin-releasing effects, the peptides mechanism of actions is poorly understood. This study investigates the impact of conjugation of tigerinin-1R with (dAla2)-GIP on the cellular uptake and anti-diabetic actions of the peptide.Method: Amphipathicity, net...

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Endocrine Abstracts

Characterization of the insulinotropic and glucose lowering actions of hybridized amphibian host defence peptide, tigerinin-1R

The conjugation of tigerinin-1r with modified gastric inhibitory polypeptide enhanced its cellular uptake and metabolic actions

BiosciAbstracts